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Panel recommends FDA approval of epilepsy drug derived from marijuana

first_img Some patients in the trials experienced sleepiness or gastrointestinal issues, and the medication did not work for all patients. There is also some concern about the effect of the drug on the liver. In the briefing documents, the FDA officials wrote that the “risk of liver injury has the potential to be serious,” but that it could be addressed by tracking liver function during treatment.Panelists said they were swayed by robust efficacy data from three clinical trials and that clinicians could easily handle any worries about side effects.“The safety concerns could be managed with labeling and monitoring,” said Jane Acri, a panel member who works in medication development at the National Institute on Drug Abuse.In sometimes emotional testimony, the parents of children with the conditions urged the panel and FDA to get the drug to the market. They described how they have to watch their children constantly, and the horror of their children’s seizures, which can be so violent they break bones. They explained the developmental setbacks their children faced and the problems with other medications and therapies they had tried.“She couldn’t go outside, she couldn’t do anything that other kids do,” said Stephen Carlin, who showed videos of his daughter, Zora, who has Dravet syndrome, having seizures. Please enter a valid email address. In a first, scientists show a marijuana component reduces seizures for some with epilepsy [email protected] An expert panel on Thursday unanimously recommended that the Food and Drug Administration approve a new medicine for two rare and devastating forms of epilepsy, paving the way for the authorization of what would be the country’s first medication made from marijuana.The 13-0 vote from the FDA advisory committee is not binding, and the agency is expected to announce its decision by the end of June. But in documents this week, FDA officials wrote they supported the approval of the drug, Epidiolex, after concluding that it cut the number of seizures in patients in clinical trials.“This is clearly a breakthrough drug for an awful disease,” said Dr. John Mendelson, a panel member and senior research scientist at Friends Research Institute.advertisement General Assignment Reporter Andrew covers a range of topics, from addiction to public health to genetics. Andrew Joseph Privacy Policy Comparing the Covid-19 vaccines developed by Pfizer, Moderna, and Johnson & Johnson Epidiolex, which is given as an oral solution, consists of cannabidiol, or CBD, a component of cannabis that does not make people high. Its manufacturer, GW Pharmaceuticals, is seeking its approval to treat Lennox-Gastaut and Dravet syndromes, two conditions that typically emerge in the first few years of life. Patients suffer from severe seizures, and an estimated 20 percent of patients die by the time they are 20 years old.In trials, patients taking Epidiolex saw their monthly seizures reduced by about 40 percent.advertisement Leave this field empty if you’re human: But after receiving Epidiolex, “her seizures went from 40 to 50 a day to only a few or none per week,” said Carlin, whose travel was paid for by GW.Some families have moved to states where marijuana is legal either recreationally or medically to obtain CBD oil for their children’s epilepsy, and some states have changed their laws to make CBD oil available. But experts have said that having an approved and regulated medication available in a standard dose is important because self-treating can expose patients to irregular doses, substandard supplies, or the risk of side effects without medical oversight.Evelyn Nussenbaum, the mother of a child with epilepsy, told the panel that she had tried to buy CBD from retailers, but that when she had it tested, she found out that many of them had lower concentrations of CBD than on the label, and some had none at all.The Drug Enforcement Administration continues to classify marijuana as a Schedule I drug, meaning it has no proven medical value and a high risk of abuse. If Epidiolex is approved, the DEA will then have to reschedule cannabidiol — given that FDA approval demonstrates a medical value — but can leave cannabis overall at Schedule 1.The FDA has previously approved synthetic medications — including Marinol and Cesamet — that resemble or are identical to THC, the component of marijuana that makes people high. The drugs, which are approved to treat nausea from chemotherapy and other conditions, are listed at Schedule III and Schedule II, respectively. HealthPanel recommends FDA approval of epilepsy drug derived from marijuana An expert panel on Thursday unanimously recommended that the FDA approve Epidiolex for two rare and devastating forms of epilepsy. Kathy Young/AP Epidiolex comes from a proprietary strain of cannabis grown by GW that has been bred to have high levels of CBD and low levels of THC.Analysts had expected a positive advisory committee recommendation, and they also expect the drug to be prescribed off-label for other types of epilepsy if it is approved. Ahead of Thursday’s advisory committee review, shares of GW Pharma were up about 7 percent this week.There are six other drugs approved to treat seizures associated with Lennox-Gastaut, but none approved for Dravet. Trending Now: Related: Newsletters Sign up for Daily Recap A roundup of STAT’s top stories of the day. @DrewQJoseph By Andrew Joseph April 19, 2018 Reprints About the Author Reprints Tags drug developmentneurologyresearchlast_img read more

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In Pictures: Fantastic Performances by Laois Marlins at the National Aquatic Centre

first_img RELATED ARTICLESMORE FROM AUTHOR TAGSLaois Marlins Pinterest WhatsApp Twitter Twitter With the start of the Long Course racing season Laois Marlins Swim Club delivered a strong performance over the last two weekends in the Leinster Long Course Qualifying Meet.Leinster LC Qualifying Meet was the first long course racing competition of the season.The 28 Laois Marlins swimmers displayed a brilliant performance over the three days achieving 47 personal bests, 1 Gold, 2 Silvers and 2 Bronze medals. In Pictures: Fantastic Performances by Laois Marlins at the National Aquatic Centre News The 14 girls representing Laois Marlins were Diana Alastal, Nora Alastal, Muireann Byrne, Fiona Carroll, Orla Colley, Klava Hayes, Rachel Igoe, Sophie Igoe, Chloe Kavanagh, Ruby Maguire, Caoimhe Moore, Sadhbh Moore, Katie O’Connor, Daniela Ryan.13 boys competed; Micheál Bergin, Cillian Bergin, Eli Brophy, Calvin Carabio, Ethan Davy, Sam Farrell, Caylem McEvoy, Noah Murphy, Leo Picard, Eric Popa, Ignat Samuchov, Vladislav Spirkin, Valera Zaharovs, and a commendation to Sam Farrell who came first place in the 50 fly.Well done to all the swimmers for their fantastic swimming in both events and to the team coaches Padriac Dolan and Judith O’Connor for their successes.Klava Hayes, Chloe Kavanagh, Ruby Maguire.Vladislav Spirkin, Caoimhe Moore, Nora Alastal, Daniela Ryan, Calvin Carabio, Noah Murphy, Katie O’Connor, Sadhbh Moore, Ethan Davy, Cillian Bergin, Rachel Igoe.Orla Colley, Muireann Byrne, Leo Picard, Caylem McEvoy, Ignat Samuchov, Fiona Carroll, Eric Popa, Diana Alastal, Ruby Maguire, Klava Hayes.Noah Murphy, Micheál Bergin, Eli Brophy, Scott Overton, Sean Donoghue, Conor Menendez, Cian Nugent, Ben Wall, Sam Farrell, Sean Zou.Eli Brophy and Coach Padraic Dolan.Coach Padriac Dolan and Sadhbh Moore.Lucy Brennan, Muireann Byrne, Caoimhe Moore, Amy Bergin, Daniela Ryan, Orla Colley, Lena Tiernan Kaminska, Toni Dolan, Sadhbh Moore, Katie O’Connor.Kuba Krawczun , Scott Overton, Sean Zou, Sean Donoghue, Conor Menendez, Cian Nugent, Ben Wall, Sam Farrell.SEE ALSO – Laois Early Years educators set to march for ‘respect’ Pinterest Bizarre situation as Ben Brennan breaks up Fianna Fáil-Fine Gael arrangement to take Graiguecullen-Portarlington vice-chair role Facebook WhatsApp Electric Picnic Electric Picnic Competing for the girls were: Nora Alastal, Amy Bergin, Lucy Brennan, Muireann Byrne, Orla Colley, Toni Dolan, Klava Hayes, Lena Tiernan Kaminska, Caoimhe Moore, Sadhbh Moore, Katie O’Connor, Daniela Ryan, Jessica Zhigulskaya.Competing for the boys were; Cillian Bergin, Micheál Bergin, Eli Brophy, Calvin Carabio, Sean Donoghue, Sam Farrell, Kuba Krawczun, Conor Menendez, Cian Nugent, Scott Overton, Sean D Scannell, Ben Wall, Valera Zaharovs, Sean Zou, Noah Murphy.A special mention to the medal winners Sean Scannell, who won a gold in the 50 backstroke and two silvers in the 200 backstroke and the 100 backstroke, Eli Brophy, who claimed a bronze in the 50 breaststroke, and Sadhbh Moore, who won a bronze in the 50 backstroke.Laois Marlins Club continued their strong start to the 2020 season with another huge crew of 27 swimmers attending the Leinster Development Meet Sunday January 27 in the National Aquatic Centre.All were looking to deliver positive swims and better their times. They certainly did that – coming home with 53 personal bests. Home Sport Other Sport In Pictures: Fantastic Performances by Laois Marlins at the National Aquatic Centre SportOther Sport Previous articleGE2020 – a bluffer’s guide to the General Election in numbersNext articleGood times continue for IT Carlow as Laois lads help hurlers to Fitzgibbon Cup final Oisín Hooney Laois Councillor ‘amazed’ at Electric Picnic decision to apply for later date for 2021 festival Facebook By Oisín Hooney – 8th February 2020 Electric Picnic organisers release statement following confirmation of new festival datelast_img read more

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Mary Theresa Lowndes: The fair deal scheme is anything but fair

first_img Facebook Twitter Pinterest By Mary Theresa Lowndes – 10th May 2020 Mary Theresa Lowndes: The fair deal scheme is anything but fair WhatsApp Facebook To demand 80% of their pension and a percentage of their property at the end of their lives after all their hard work is a blatant, downright and bare-faced robbery.All decent people want to leave whatever bit of money and property they have to their children and grandchildren. Also Irish people like to keep property in the family name if at all possible. This tradition is very important, especially to rural people, and it is a worry for many elderly people.The average cost of a nursing home is in or around €1,000 per resident per week. Some of this comes from the residents income and their property and the rest is subsidised by the HSE.The government is giving extra financial help to nursing homes during the Covid-19 crisis. The health care assistants who are trained have to work for low pay which is very unfair. The private nursing homes are for profit.When a person applies for the unfair fair deal or a family member applies on their behalf they have to fill an application form and provide proof of their income, usually a pension, and if they own their own home and property they have to provide proof also.They have to get their property valued by an auctioneer. That is their privacy gone straight away. And older people find it very hard to have to divulge their business to anyone and no blame to them. They will pay 80% of their pension and according to the HSE“You will also pay 7.5% (3.75% if you are part of a couple) of your assets such as land or property. The first €36,000 (€72,000 if you are part of a couple) of your assets is excluded from the assessment”I detest and resent the fact that the family home is assessed. To the HSE it is a house. But to the owner it is a home filled with memories and they want to pass it on to their own flesh and blood. The HSE goes on to point out:“The main property where you live will only be included in the financial assessment for three years while in care. This is known as the 22.5% or ‘three-year cap”.22.5% amounts to a lot of money, reducing the value of the house for the person inheriting it. It will reduce the value of the house that became a loving home.A farm or business is not safe either. But the three year cap will apply to a farm or business if the person became suddenly ill or had a sudden accident resulting in the need for long term care and if the person ran the business or farm up to the time of the sudden illness.And it is also a requirement that a family member show proof that he or she will continue to manage the farm or business. But even with the three year cap on the farm or business it will amount to a substantial sum of money and may plunge the inheritor into serious debt.And all of that doesn’t cover extras. I know families who were billed for things like a tube of arnica cream, medication not covered by the medical card, chiropody etc.I heard of a situation where a resident liked milk and the family had to bring in a pint of milk when visiting. And if you go into care and you signed over your property to a child within the last five years they will look at that too and assess it.They don’t take your children’s income into consideration, how very kind of them. You can read the whole complicated details on the HSE site. Also check out Citizens Information.I believe that everyone should protest against this unfair fair deal. And people should not sign up for it. If enough people refused it they would have to get rid of it.Our state should respect the elderly and thank them for their contribution to the state by giving them free and compassionate care during their final years, preferably in their own home. Nursing homes should be the very last resort.And if it has to be a nursing home, protest about the unfair fair deal and do not sign up for it.SEE ALSO – Mary Theresa Lowndes: The Ireland of old was not the most pleasant of places WhatsApp Twitter Electric Picnic Previous articleWATCH: Spectacular lightning hits Laois as temperatures set to drop this weekNext articleA birthday surprise, Exams and Electric Picnic – It’s all in our Tweets of the Week Mary Theresa LowndesMary Theresa Lowndes describes herself as a ‘Golden Oldie’ living in her 60s. She went to college late in life as a mature students and has a degree in Sociology and Social Policy from Trinity College and a masters in journalism from DIT. Home Columnists Mary Theresa Lowndes: The fair deal scheme is anything but fair Columnists Pinterest Electric Picnic organisers release statement following confirmation of new festival date RELATED ARTICLESMORE FROM AUTHOR Laois Councillor ‘amazed’ at Electric Picnic decision to apply for later date for 2021 festival Electric Picnic The residents in the homes never went anywhere so the disease was brought to them. The minute there was the slightest hint of a virus in China the nursing homes and everywhere else should have been preparing.It is very hard for a person facing the end of life. To be aware that one will never ever see one’s family or grandchildren again is the greatest heartbreak anyone will ever face.And people deserve free end of life care, preferably in their own homes. A nursing home should be a last resort and all nursing homes should be public.Most elderly people were the people who got up early in the morning. They looked after their families and built up our country.Many of them went through very hard times and worked very hard. Many worked hard jobs for low pay and scrimped and struggled so that they would own their own homes. Home ownership is very important to Irish people because it makes them feel safe and secure. Electric Picnic TAGSFair Deal Scheme I have no time for nursing homes. The old people used to call them the home. And to have to end up in the home was a shocking thing.And now I realise that they were right. Residents no longer have control over their finances or their lives and freedom and privacy is no more. It is very unfortunate and sad when a person has to go into a nursing home.But you would expect your family member to be safe in these places. Covid-19 has become a huge problem for nursing homes and many residents have sadly passed from the virus. Electric Picnic apply to Laois County Council for new date for this year’s festivallast_img read more

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ASC reciprocates bans against Beryl Henderson

first_img Share this article and your comments with peers on social media Mouth mechanic turned market manipulator An has ASC panel ordered that Henderson: > must cease trading in or purchasing securities permanently; > is permanently banned from using any exemptions contained in Alberta securities laws; and > is permanently prohibited from becoming or acting as a director or officer of any issuer, registrant or investment fund manager, or becoming or acting as a registrant, investment fund manager or promoter. IE Staff PwC alleges deleted emails, unusual transactions in Bridging Finance case BFI investors plead for firm’s salecenter_img The Alberta Securities Commission (ASC) has reciprocated bans the Ontario Securities Commission (OSC) imposed against Beryl Henderson. In an August 2013 settlement agreement with the OSC, Henderson acknowledged that she illegally sold at least $474,000 in securities of Go Sports Entertainment Inc., a Nevada corporation, and engaged in related fraudulent conduct. Henderson had also pleaded guilty to related criminal charges. (See Investment Executive, Convicted fraudster banned from markets, September 24, 2013.) Keywords Fraud,  EnforcementCompanies Alberta Securities Commission, Ontario Securities Commission Related news Facebook LinkedIn Twitterlast_img read more

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‘Build Future’ announced as theme for National Apprenticeship Week 2021

first_img‘Build Future’ announced as theme for National Apprenticeship Week 2021 Theme of ‘Build the Future’ announced for NAW2021Focus on how employers train, retain and achieve with apprenticeshipsToolkit available online to assist the apprenticeship community in getting involved“Build the Future” is the theme for NAW2021, taking place between 8 and 14 February 2021, aiming to encourage everyone to consider how apprenticeships help individuals to build the skills and knowledge required for a rewarding career.The 14th annual week-long celebration of apprenticeships, taking place across England, will showcase the impact apprenticeships can have on communities, local businesses and regional economies and how they all benefit from the impact of apprenticeships.As a result of the pandemic and many individuals relying on technology and virtual meetings more than ever, National Apprenticeship Week 2021 will be different, but just as exciting. NAW2021 will celebrate the motivating stories of how apprentices have helped business adapt and build during a difficult year.Minister for Apprenticeships and Skills, Gillian Keegan said:Apprenticeships are a fantastic way to learn while you earn, opening up new and exciting career paths that can transform lives. It’s been a tough year for everyone, but we want the theme for National Apprenticeship Week 2021 to be a springboard to look ahead to how apprenticeships can futureproof workforces and boost careers.The week is a great opportunity to highlight the huge range of apprenticeships on offer – from Space Engineer to Registered Nurse. There are currently around 7,000 apprenticeship opportunities available on the Find An Apprenticeship website which will benefit individuals, businesses and local communities. I encourage everyone to get involved and help make it a success.To support National Apprenticeship Week 2021, individuals, employers, training providers and communities are being encouraged to get involved, to celebrate apprenticeships and how they:TRAIN apprentices, and future proof their workforce and careers though apprenticeships;RETAIN apprentices, gaining the skills and knowledge needed by the business, and seeing apprentices thrive, whilst having impact;ACHIEVE a real return on investment from apprentices; realising the business benefits of apprenticeships, with apprentices progressing in their chosen careers.Peter Mucklow, Director, Apprenticeships, Education and Skills Funding Agency said:There is no doubt that National Apprenticeship Week 2021 will be different this year in how we celebrate apprenticeship success.We are however continuing to ask employers to encourage everyone to consider how apprenticeships can help build organisations for years to come; whilst showing the clear return on investment realised when apprentices are brought into the business. Employers are helping the nation to #BuildTheFuture through apprenticeships.The diversity of career options and industries available now, through apprenticeships, is outstanding. We want all current apprentices from all sectors to get behind the Week and to showcase the positive impact of apprenticeships, on careers, families and communities.A toolkit is available now to support the apprenticeship community with planning their activity for National Apprenticeship Week 2021. Download the toolkit from GOV.UK.Keep up to date with National Apprenticeship Week 2021 updates by following /Public Release. This material comes from the originating organization and may be of a point-in-time nature, edited for clarity, style and length. View in full here. Why?Well, unlike many news organisations, we have no sponsors, no corporate or ideological interests. We don’t put up a paywall – we believe in free access to information of public interest. Media ownership in Australia is one of the most concentrated in the world (Learn more). Since the trend of consolidation is and has historically been upward, fewer and fewer individuals or organizations control increasing shares of the mass media in our country. According to independent assessment, about 98% of the media sector is held by three conglomerates. This tendency is not only totally unacceptable, but also to a degree frightening). Learn more hereWe endeavour to provide the community with real-time access to true unfiltered news firsthand from primary sources. It is a bumpy road with all sorties of difficulties. We can only achieve this goal together. Our website is open to any citizen journalists and organizations who want to contribute, publish high-quality insights or send media releases to improve public access to impartial information. You and we have the right to know, learn, read, hear what and how we deem appropriate.Your support is greatly appreciated. All donations are kept completely private and confidential.Thank you in advance!Tags:business, career, community, Download, education, future, Government, Impact, Internet, Investment, Minister, nurse, space, technology, UK, UK Government, websitelast_img read more

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Entrepreneurially minded students sought for Innovation Action Team

first_img Published: July 18, 2017 The CU Boulder Innovation Action Team is seeking entrepreneurially minded students from all majors to be part of a founding team of students to lead innovative efforts on campus. The team will ensure that the campus Innovation and Entrepreneurship Initiative (I&E) is effectively serving the needs of students by helping coordinate, plan and program fun entrepreneurial experiences at all levels.Interested in joining the Innovation Action Team? The deadline for applications is 11:59 p.m. Friday, July 28. Apply nowComposition of teamApproximately 10 applicants will be selected to participate in 2017–18 Innovation Action Team. The group is seeking highly motivated students and postdoctoral scholars from a diverse range of disciplines, ages and entrepreneurial experience who demonstrate strong entrepreneurial spirit and aptitude.Team member expectationsInnovation Action Team members will be expected to participate in one-hour team meetings every other week during the academic year and provide two hours of leadership and support per week in the following capacities:Attend and volunteer at I&E related events (e.g., New Venture Challenge events, Entrepreneurship Unplugged).Lead the programming of additional panels, workshops or sessions that you think should happen on campus—and make them happen.Tell your friends and other students and scholars about the awesome I&E activities that are available.Questions? Email Sarabeth Berk, assistant director for the Innovation & Entrepreneurship Initiative, at [email protected] Share Share via TwitterShare via FacebookShare via LinkedInShare via E-maillast_img read more

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New Wines from Amare Stoudemire, + Award-Winning Rose, Red and Sparkling…

first_imgPinterest Facebook Home Industry News Releases New Wines from Amare Stoudemire, + Award-Winning Rose, Red and Sparkling Wines…Industry News ReleasesWine BusinessNew Wines from Amare Stoudemire, + Award-Winning Rose, Red and Sparkling Wines from Royal Wine CorpBy Press Release – February 15, 2021 1090 0 TAGSAmare StoudemireRoyal Wine/Kedem Email Share Twitter AdvertisementThe question posed annually at the Passover Seder – “Why is this night different from all other nights” – takes on a special meaning again this year. No doubt, this year’s Seder will be unusual, but the trying circumstances can also be an opportunity to relate to aspects of Passover in a different manner than in the past. Central to the Seder is the commandment to drink four cups of wine. Should it be just any wine? Or should this year’s four cups be filled with the finest?(Bayonne, NJ, FEB 15, 2021) — This Passover, spend your holiday in Israel, Italy, or France — without ever having to leave your Seder table. NJ-based Royal Wine, the world’s largest purveyor of kosher wines and spirits, offers exceptional Passover selections from around the globe – including a label from NBA All-Star Amaré Stoudemire — in a wide range of tastes and prices.Kosher wines have experienced a renaissance over the past two decades. Believe it or not, the best-selling imported Moscato in the U.S. happens to be kosher! Experience outstanding kosher options at any price point. New varieties from wineries around the world make kosher wines a great choice for everyone. Whether for the Passover Seder or at a simple dinner with friends, these top-quality wines are sure to satisfy on all occasions.Stoudemire Origins 2018 and Stoudemire Clarity Rosé 2020 – After establishing a line of kosher wines produced in the Upper Galilee (imported and distributed by the Royal Wine Corp.), Amare expands his offerings to California in collaboration with Herzog Wine Cellars (USA). SRP: $24.99.Herzog Lineage Rosé 2020– This casual rosé’s flavors include pomegranate, raspberry, and tart cherry (USA). SRP 19.99Château Roubine Rosé 2020 (Côtes de Provence, France) – The rosé wines of this top-ranking classed growth Provence Château are now imported exclusively by Royal Wine Corp. and are kosher for Passover, as well. SRP: 19.99-59.99Herzog Generation IX Cabernet Sauvignon Stags Leap District Napa Valley 2018 – Herzog’s new flagship wine from the prized Stags Leap district, famous for putting California on the world wine map in 1976 (USA). SRP: $249.99Bartenura Prosecco Rosé – Top quality pink sparkling wine from Italy, great for the Passover seder and all year round for small family gatherings and celebrations (Italy). SRP: 19.99Château Meyney Saint-Estèphe 2018 – This famed Bordeaux Estate joins Royal’s family of high-end Bordeaux Châteaux producing kosher varieties (France). SPR: $79.99Sforno –  A new line of high value, affordable quality kosher wines produced by the celebrated Riglos winery, and retailing between $10-15 (Argentina).Can’t get enough of these stellar releases? Here are some more offerings from around the world:Israel:Gush Etzion, a great boutique winery in the Judean Hills returns to America with an impressive array of high-quality wines. SRP: $22.99 – $59.99Barkan Reserve Cabernet Sauvignon, a practically unmatched wine in quality and price ($19.99).FranceChampagne Barons De Rothschild, an elegant and classic champagne from this famed family of wines ($79.99)Chateau Lascombes 2018, A Grand Cru from Margaux; SRP: $159.99ItalyBartenura, Rosato Cans, after the successful launch of Bartenura Moscato Cans, here comes the Rose version! SRP: $14.99/four-packChileAlfasi Reserve Carmenere, top QPR Carmenere from this booming New World region SRP: $10.99ArgentinaFlechas de Los Andes Gran Malbec, Malbec from part of the Rothchild wine estates SPR: $29.99Kosher For Passover VodkaLVOV Vodka distilled from beets; SRP: $20What Makes Kosher Wine Kosher? – Ten Things to Know About Kosher Wine“People may be surprised to learn that most kosher wines are certified for year-round use, as well as for Passover,” says Jay Buchsbaum, VP Marketing & Wine Education, Royal Wine Corp. Here are more facts to help you understand what makes wine kosher:10 Things to Know about Kosher Wine;   www.TheKFWE.com  (Virtual Wine Fest, FEB 21)Passover 2021 begins sundown MARCH 27About Royal Wine/KedemFounded in 1848, Royal Wine Corp. has been owned and operated in the United States by the Herzog family, whose winemaking roots go back eight generations to its origin in Czechoslovakia.Today, Royal Wine’s portfolio of domestic and international wines range from traditional wine producing regions of France, Italy, and Spain, as well as Israel, New Zealand, Argentina and more. The company owns and operates the Kedem Winery in upstate New York, as well as Herzog Wine Cellars in Oxnard, California, a state-of-the-art-facility featuring guided wine tours, a fully staffed modern tasting room, gift shop and catering facilities. Additionally, the winery houses the award-winning restaurant Tierra Sur, serving the finest, Mediterranean-inspired, contemporary Californian Cuisine. Follow Royal Wine Corp at: @royalwinecorp; https://www.facebook.com/RoyalWineCorpAdvertisement ReddIt Linkedin Previous articleUnderstanding Vineyard, Winery, Farm and Ranch Valuation and State of the Market with David Bolster, Century 21 Select PlacervilleNext articleRead All About It: Papapietro Perry Crafts Winning Red Press Releaselast_img read more

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Healthcare spends, making India slum-free should be govt’s priority: Experts

first_img By Press Trust of India on July 12, 2020 Add Comment Comments (0) Phoenix Business Consulting invests in telehealth platform Healpha Aatmanirbhar BharatAzim Premji UniversityCOVID-19 crisisinvest in healthNational Institute of Public Finance and Policyslum free IndiaYale University News Public Health Share WHO tri-regional policy dialogue seeks solutions to challenges facing international mobility of health professionals Healthcare spends, making India slum-free should be govt’s priority: Experts The missing informal workers in India’s vaccine story MaxiVision Eye Hospitals launches “Mucormycosis Early Detection Centre” Read Article Heartfulness group of organisations launches ‘Healthcare by Heartfulness’ COVID care app At the seventh economic conclave – organised by State Bank of India held recently, the economists were unanimous on laying greater thrust on decentralisation of policy-making in futureThe government can turn COVID-19 crisis into an opportunity by investing in healthcare, and it should also pursue making all the cities slum-free by 2023, according to economists.At the seventh economic conclave – organised by State Bank of India held recently, the economists were unanimous on laying greater thrust on decentralisation in policy-making in the future, as a one size fits all approach may not work always.India at present has the third-highest number of COVID-19 cases after the US and Brazil and has already lost over 22,000 people.“It is very concerning that a lot of this discussion of the Aatmanirbhar (Bharat) package or other packages are not talking at all about what investments are taking place in the health sector. How much are we spending on testing, basic information campaigns? This is a health induced crisis, you got to respond to that to respond to the economy,” Rohini Pande, who is associated with Yale University, said.India has historically under-invested in health and the increase is not very much right now as well, she said, stressing that we need to recognise that for economic recovery, humanitarian and health crisis are all interlinked.“To change this crisis to an opportunity, let us invest in the health sector,” SBI’s chief economist SK Ghosh said, suggesting a plan to build a 500-bed hospital in 250 districts for Rs 60,000 crore over the next two years.Pande said frontline health workers are not paid, and we can immediately start paying them and expand their base, which will lead to better case spotting and also contact tracing.Arjun Jayadev with Azim Premji University said concerns on the health infrastructure affect the broader economy as well and pointed out that the animal spirits can only be rekindled once the fear of health shock goes away.“Many migrant labourers may not want to return to the cities not just because they are not getting a good conducive environment to live, but they are bothered about their health condition as well,” he said.The Indian economy runs on two gears – one which have access to expensive private healthcare and the others who don’t, Jayadev said, adding that universalisation of services should be a key theme while investing the money.“You have this horrific situation where 5 lakh die of TB, 1.5 lakh children die and we don’t bat an eyelid, except when the situation comes to us as COVID,” he added.Rathin Roy in National Institute of Public Finance and Policy (NIPFP) suggested a radical change in output measurement where gains on agriculture, health, education and housing become the lead indicators of economic strength rather than focusing on automobile sales and FMCG good sales.Roy also proposed making a slum-free India as a policy objective by 2023.“It is obvious from the migrant labour problem, it is obvious from the COVID situation that a slum-free India (by) 2023 should be our objective. I do not see enough economists, enough policymakers, even mentioning a slum-free India,” he said.All the economists also seemed to agree that the Reserve Bank of India will have to monetise a part of the fiscal deficit this year due to the extreme strain on government finances, but did not offer a quantum or timeline. Menopause to become the next game-changer in global femtech solutions industry by 2025 Related Posts Indraprastha Apollo Hospitals releases first “Comprehensive Textbook of COVID-19”last_img read more

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About Orphan Genes — What’s the Big Problem for Evolution?

first_imgBillions of Missing Links: Mysteries Evolution Can’t Explain Origin of Life: Brian Miller Distills a Debate Between Dave Farina and James Tour Ann GaugerSenior Fellow, Center for Science and CultureDr. Ann Gauger is Director of Science Communication and a Senior Fellow at the Discovery Institute Center for Science and Culture, and Senior Research Scientist at the Biologic Institute in Seattle, Washington. She received her Bachelor’s degree from MIT and her Ph.D. from the University of Washington Department of Zoology. She held a postdoctoral fellowship at Harvard University, where her work was on the molecular motor kinesin.Follow AnnProfile Share Recommended Email Print Google+ Linkedin Twitter Share TagsATPbivalvesDarwinian theoryDNADouglas AxeevolutionEvolution and TinkeringexpectationsexperimentsFrançois Jacobfunctiongenome sequencinginsectsintelligent designnucleotide sequencesorphan genesprotein foldsRNAsequence spacetranscription,Trending Congratulations to Science Magazine for an Honest Portrayal of Darwin’s Descent of Man Email Print Google+ Linkedin Twitter Share Orphan genes — genes that are present in only one species, or a group of closely related species — are of particular interest to advocates of intelligent design. The reason for this has to do with the assumptions of evolutionary biology.The main evolutionary assumption is common descent, that all life is descended from one or a few ancestors. Following from this, and taken as evidence for this, is the assumption that all life shares DNA in common. Prior to the advent of widespread genome sequencing, it was assumed that living things shared genes, that there was a set of shared housekeeping genes, and a set of genes specific to a taxonomic group, though these would be few in number. It was assumed that the vast majority of genes would be found multiple places in the genomes of living things. The reason? It was assumed that getting new genes was hard, and once a workable solution was found it would be preserved in the descendants that followed. The bulk of genes would have been invented early in evolution, and thus would be broadly shared.When It All ChangedBut all that changed when many genomes were sequenced and their transcripts analyzed. Each genome, or each taxonomic group, such as bivalves or insects, was found to contain unique genes, found only in that group or species. This was a surprise. At first it was attributed to incomplete sampling. As more genomes were sequenced, it was thought, the uniqueness would turn out to be illusory. Other organisms would carry those genes. As a related explanation, the sparsity of their distribution might be due to horizontal gene transfer, or to gene loss. The hypothesis was that what appeared to be unique was so because it was the result of some rare transfer between species, and we hadn’t identified the source. Or what once was widespread had been lost over evolutionary time.These explanations are not proving true. First, the more genomes that are sequenced, the more the proportion of orphans should shrink, as more and more “orphans” should be shown to be present in other genomes. But that has not proven to be the case. The mountain of orphan genes is growing, not shrinking. Similarly, horizontal gene transfer was not born out. The sister genes of orphans should have been found as sample size increased, reducing the proportion of orphan genes. As for gene loss as an explanation, it would have to be too massive to be realistic to account for the patterns seen.One last possibility. The orphans could be related to other genes, but their sequences could have diverged so much as to be unrecognizable. Only their protein structures might reveal relatedness. This also has not been born out by studies that have determined structures of orphan proteins.A Sea Change in Evolutionary ThinkingSo what’s the solution? If you are an evolutionary biologist, it’s simple. You decide it must be easy to get new genes directly from random (non-coding) DNA, or by frameshift or overlapping genes (which amounts to random sequence). This represents a sea change in evolutionary thinking.Now hold it. Saying that it’s easy to get new genes from DNA by those methods overturns a major Darwinian expectation. In 1977, in his famous article “Evolution and Tinkering,” which has been cited many thousands of times, the Nobel laureate François Jacob explained the accepted view of how evolution constructed new genes:…once life had started in the form of some primitive self-reproducing organism, further evolution had to proceed through alterations of already existing compounds. New functions developed as new proteins appeared. But these were merely variations on previous themes. A sequence of a thousand nucleotides codes for a medium-sized protein. The probability that a functional protein would appear de novo by random association of amino acids is practically zero. In organisms as complex and integrated as those that were already living a long time ago, creation of entirely new nucleotide sequences could not be of any importance in the production of new information. [p. 1164; emphasis added.]New genes must arise from pre-existing genes, leaving the signal of ancestry in their closely related (i.e., homologous) sequences, because the probability of the alternative is “practically zero.” That’s why the discovery of orphan genes, which show no homology to other sequences, came as a great surprise.No Problem, You Say?“No problem. Isn’t that what science supposed to be about?” said one evolutionist to me. “Adapting your theory to fit the facts?”Well, theories have to be amenable to falsification too. They can only bend so far.So how can we tell whether genes are easy to get or hard? By testing these alternatives in the lab.At present the preferred theory for the birth of new genes is to take a stretch of DNA that is currently not being transcribed into RNA, then let it acquire the signals necessary for transcription, then have that new transcript have a function, either as an RNA or after being translated into protein. This is in fact how many orphan genes are found. An RNA transcript is made in one species from a stretch of DNA that in a sister species does not make RNA. Further work then determines if the RNA is translated into protein, and ultimately, if the protein has a function.But in order for this scenario for orphan gene creation to work, functional protein sequences have to be easy to acquire, within reach of an evolutionary search starting from an existing non-functional stretch of DNA. Evolutionists tend to think that such a thing happens easily. Evolutionary processes can produce a new gene or structure or chemical activity easily. This must be true if evolutionary processes are the explanation for orphan genes.The Rarity of Functional Protein FoldsIn contrast, ID proponents think that it’s very difficult to get function from random sequence. There’s a definite reason for this. Experiments by Dr. Douglas Axe measured the rarity of functional protein folds in sequence space (only 1 in 10^77 proteins form a fold with a target function, a very, very, very small number). If functional proteins are very rare in sequence space, that makes it very difficult to get new genes or structures or chemical activities. Others have found similar answers, when asking for the requirements to produce an enzymatic activity. Others, when asking for simple kinds of activity, like sticking to a column loaded with a substrate like ATP, get numbers that are conceivably within range of evolutionary processes. Just sticking to a column is not nearly as demanding as carrying out an enzymatic reaction. There are strong points of view as to the reliability of the various methods. How the various experiments are judged tends to be influenced by one’s particular view on the question of evolution. So the best thing is to do more experiments, which is precisely what the scientific community is doing. Work is in progress now in many labs to test the question of how hard it is to get an orphan gene from non-coding sequence. Some are asking how hard it is to get a promoter (necessary to promote active transcription). Some are asking how likely it is for random sequence to have function. The sticking point, literally, seems to be that random sequences don’t fold properly and are insoluble in water. They aggregate. That makes most kinds of function difficult, to say the least. Lastly, how likely is it that the function will actually be helpful? We’ll see.The answer is not in. If Doug Axe is right (and remember, he is not the only researcher to have found that functional proteins are very rare in sequence space), then getting an orphan gene by an evolutionary process is extremely unlikely. But orphan genes are possible, maybe even to be expected, when a designing intelligence acts.Photo: Leafcutter ants in the Wilhelma Zoo, Germany, by Pjt56 [CC BY-SA 4.0 ], from Wikimedia Commons. Evolution About Orphan Genes — What’s the Big Problem for Evolution?Ann GaugerNovember 6, 2018, 4:59 AM A Physician Describes How Behe Changed His MindLife’s Origin — A “Mystery” Made AccessibleCodes Are Not Products of PhysicsIxnay on the Ambriancay PlosionexhayDesign Triangulation: My Thanksgiving Gift to All “A Summary of the Evidence for Intelligent Design”: The Study Guide Jane Goodall Meets the God Hypothesislast_img read more

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Clifton nets hat trick; Victor rallies to double up Greece Athena

first_img The Victor Blue Devils rallied to defeat Greece Athena, 6-3 for their fifth straight win. (Photo: Paul Gotham)By PAUL GOTHAMROCHESTER, N.Y. — Their rally cry is “Why Not Us?” After Monday’s performance, it’s easy to picture the Victor boys’ soccer team contending for the upcoming sectional championship.Trevor Clifton connected on three first-half goals, and the Victor Blue Devils rallied to defeat the Greece Athens Trojans, 6-3 in non-league action Monday.Clifton gave Victor’s its first lead of the game in the 20th minute at 3-2 when the senior attacker took advantage of a loose ball in the 18-yard box.“Spencer (Ryczek) won that ball in the box,” Clifton said of his teammate who challenged for a header. “I just saw the ball bounce right in front of me. I had to make the play. I slid. Lucky to get a foot on it and go in.”The Blue Devils took control from there.Clifton found back of the net from 30 yards out in the 32nd minute and five minutes later he made it a 6-2 game when he got a head on teammate Mason Perry’s direct kick.“I barely hit that ball,” Clifton noted. “I got the slightest nick on it. It could’ve been Mason’s goal. All it took was a little touch. The goalie didn’t know what was going on, so he didn’t have time to react. It was a perfect ball.”Perry’s service came from 40 yards away.“I saw Trevor raise his hand,” Perry explained. “He was taller than the defender, so it was a mismatch. I played a driven ball into him. I knew he was going to get it.He had the slightest nick on it, a perfect deflection. It wouldn’t have gone in without him. Great goal.”Victor trailed early by deficits of 1-0 and 2-0 before Andrew Crean got the equalizer with a blast from outside the 18-yard box.Ryczeck got the Blue Devils on the board in the game’s 12th minute.“They were all over us the first ten minutes,” Victor coach Steve Fish said. “After that first goal we settled in and took a deep breath and realized we can play with them. We can possess. We can knock the ball around. Up until that first goal we looked a little rattled.”The effort was Clifton’s second three-goal game in the past seven days having netted a trifecta in a 5-1 win over Gates-Chili last Wednesday. He now has 13 goals on the season.“I got to thank my teammates for getting me the ball in perfect spots,” Clifton said. “If it wasn’t for them, I don’t have a hat trick today.”The win was the fifth straight for Victor which improved to 8-4-0 on the season.“It feels really good,” Perry said of the current streak. “We started off little shaky. We’re getting better as it goes on. We should be ready for the big show.”Ryczek finished with two goals and an assist.Othman Belseine got Athena on the scoreboard less than three minutes into the game. Max Wright gave Athena a 2-1 edge in the 15th minute, but the Trojans struggled the rest of the half as Victor found success in counter-attack situations.“We just didn’t come to play,” Greece Athena coach Mike Butler said. “We could have been up 3-0 early then we’re just giving up breakaway after breakaway. We’ve been good all year We’ve never not shown up to play, so that was disappointing.”Athena’s Ryan Lindeman scored the lone second-half goal. The senior rung the crossbar early in the second stanza and later drilled the post.“He’s just a magician with the ball,” Fish said of Lindeman. “The way he dribbles and takes on people, it’s only a matter of time. He stung us in the second half, but he rung two off bars. It was just our night. They didn’t get their chances to go in, and we finished all of ours.”The loss was the second straight for Athena (8-3-2) which fell to Fairport, 2-0 on Saturday.“It was a game that we were geared up for,” Butler said of the loss to Fairport. “We played okay there. We played hard. Fairport is really good. We didn’t get that done. What are you going to do? It happens.”Athena hosts Brockport on Wednesday. A 4:30 p.m. kickoff is scheduled.Visit hosts Penfield also on Wednesday. A 7:30 start time is slated.  Greece Athena, Greece Athens Trojans, Trevor Clifton, Victor Blue Devils Clifton nets hat trick; Victor rallies to double up Greece Athena added by Paul Gotham on October 3, 2016View all posts by Paul Gotham →FacebookTwitter分享by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksSponsor ContentBig Data Courses | Search AdOnline Big Data Courses Might Be Better than You ThinkBig Data Courses | Search AdCosmoWomensTop 30 Most Beautiful Women in the WorldCosmoWomensLovely&HealthyTop 10 Most Dangerous Cruises In The World Lovely&Healthyby Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksMore from Pickin’ SplintersBaron keeps Bonaventure close to his heart – Pickin’ Splinters”If you had a Mount Rushmore of MCC baseball, he’s on there.” Longtime assistant Jack Christensen passes away – Pickin’ SplintersFormer Tribune Vennaro signs with Milwaukee – Pickin’ Splinters By Paul Gotham on October 3, 2016No Comment Follow on Facebook Clifton nets hat trick; Victor rallies to double up Greece Athena Print This Post Subscribe by Emailcenter_img Add to Google+ Connect on Linked in Share on Facebook This site uses Akismet to reduce spam. 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